Motif ID: TAL1_TCF{3,4,12}.p2

Z-value: 1.542


Transcription factors associated with TAL1_TCF{3,4,12}.p2:

Gene SymbolEntrez IDGene Name
TAL1 6886 T-cell acute lymphocytic leukemia 1
TCF12 6938 transcription factor 12
TCF3 6929 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
TCF4 6925 transcription factor 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TCF4chr18_-_51406359-0.533.4e-02Click!
TCF3chr19_-_16012460.214.4e-01Click!
TAL1chr1_-_474680290.175.3e-01Click!
TCF12chr15_+_54998144-0.097.4e-01Click!


Activity profile for motif TAL1_TCF{3,4,12}.p2.

activity profile for motif TAL1_TCF{3,4,12}.p2


Sorted Z-values histogram for motif TAL1_TCF{3,4,12}.p2

Sorted Z-values for motif TAL1_TCF{3,4,12}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TAL1_TCF{3,4,12}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr22_+_43451600 3.725 PRR5
proline rich 5 (renal)
chrX_-_154216929 2.787 NM_001289
CLIC2
chloride intracellular channel 2
chr12_-_101835183 2.522 PAH
phenylalanine hydroxylase
chr1_-_149004852 2.513 CTSS
cathepsin S
chr16_+_56286212 2.293 NM_032269
CCDC135
coiled-coil domain containing 135
chr2_+_169367345 2.283 NM_001039724
NM_001171632
NM_052946
NOSTRIN


nitric oxide synthase trafficker


chr19_-_44060729 2.249 NM_001195833
NM_198445
RINL

Ras and Rab interactor-like

chr19_+_40224480 2.223 HPN
hepsin
chr2_+_108360798 2.144 NM_006588
SULT1C4
sulfotransferase family, cytosolic, 1C, member 4
chr9_-_129707392 2.143 LOC100131355
ST6GALNAC6
hypothetical protein LOC100131355
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chr17_+_38256886 2.114


chr12_-_101835026 2.047 PAH
phenylalanine hydroxylase
chr12_-_101835510 2.015 NM_000277
PAH
phenylalanine hydroxylase
chr1_+_32489426 1.839 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chr22_+_38652555 1.702 GRAP2
GRB2-related adaptor protein 2
chr2_-_233586145 1.678 NGEF
neuronal guanine nucleotide exchange factor
chr16_-_67943157 1.571 NM_144676
TMED6
transmembrane emp24 protein transport domain containing 6
chr2_-_233586164 1.567 NM_019850
NGEF
neuronal guanine nucleotide exchange factor
chr1_-_149004879 1.510 CTSS
cathepsin S
chr2_-_55131157 1.501 RTN4
reticulon 4
chr22_+_22907443 1.494 NM_019601
SUSD2
sushi domain containing 2
chr17_-_53761119 1.451 NM_004758
NM_024418
BZRAP1

benzodiazapine receptor (peripheral) associated protein 1

chr2_-_55131176 1.428 RTN4
reticulon 4
chr2_-_158008763 1.418 NM_004288
CYTIP
cytohesin 1 interacting protein
chr16_-_29818334 1.386 SEZ6L2
seizure related 6 homolog (mouse)-like 2
chr1_-_176205672 1.361 NM_033127
SEC16B
SEC16 homolog B (S. cerevisiae)
chr16_+_11966464 1.295 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr17_+_38256710 1.276 NM_003734
AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr2_-_55131124 1.268 RTN4
reticulon 4
chr11_-_5212168 1.226 NM_000519
HBD
hemoglobin, delta
chr19_+_17499064 1.204 FAM129C
family with sequence similarity 129, member C
chr1_-_158948176 1.194 NM_001778
CD48
CD48 molecule
chr12_+_115481568 1.179 NM_001085481
MAP1LC3B2
microtubule-associated protein 1 light chain 3 beta 2
chr11_+_5367182 1.169 NM_001004756
OR51M1
olfactory receptor, family 51, subfamily M, member 1
chr22_+_22907417 1.149 SUSD2
sushi domain containing 2
chr3_-_196792274 1.147 NM_001647
APOD
apolipoprotein D
chrX_+_48127911 1.111 NM_001034832
NM_001040612
NM_005636
NM_175729
SSX4B

SSX4

synovial sarcoma, X breakpoint 4B

synovial sarcoma, X breakpoint 4

chr2_-_151854619 1.090 NM_004688
NMI
N-myc (and STAT) interactor
chr10_-_73518772 1.079 NM_001134434
NM_014767
SPOCK2

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2

chr14_-_93493519 1.071 NM_016150
ASB2
ankyrin repeat and SOCS box containing 2
chr8_+_21967008 1.057 NM_001114137
EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr22_-_41672990 1.056 NM_007229
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chr1_-_149004916 1.044 NM_004079
CTSS
cathepsin S
chr2_-_55131202 1.040 NM_020532
NM_153828
NM_207520
RTN4


reticulon 4


chr22_+_23309717 1.034 NM_013430
GGT1
gamma-glutamyltransferase 1
chr22_+_34979118 0.989 APOL1
apolipoprotein L, 1
chrX_+_46825179 0.988 RGN
regucalcin (senescence marker protein-30)
chr2_-_188086612 0.958 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr1_-_6343306 0.953 NM_181865
ACOT7
acyl-CoA thioesterase 7
chr1_+_100099353 0.944 NM_000645
AGL
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
chr4_+_73123712 0.940 NM_001144756
NM_053036
NPFFR2

neuropeptide FF receptor 2

chr1_+_108904493 0.923 NM_001010883
FAM102B
family with sequence similarity 102, member B
chr2_-_25320299 0.919 DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr21_-_33107813 0.916 NM_001162495
NM_001162496
NM_019596
C21orf62


chromosome 21 open reading frame 62


chr16_-_29817841 0.895 NM_001114099
NM_001114100
NM_012410
NM_201575
SEZ6L2



seizure related 6 homolog (mouse)-like 2



chr1_+_242283129 0.878 NM_006352
ZNF238
zinc finger protein 238
chr2_-_55131096 0.864 RTN4
reticulon 4
chr7_+_113853790 0.861 NM_001172767
NM_148899
FOXP2

forkhead box P2

chr7_+_138695537 0.846 LUC7L2
LUC7-like 2 (S. cerevisiae)
chr6_-_41811916 0.844 NM_001167827
TFEB
transcription factor EB
chr10_+_11246934 0.842 NM_001025076
NM_001083591
CELF2

CUGBP, Elav-like family member 2

chr1_-_92724181 0.835 NM_001127216
GFI1
growth factor independent 1 transcription repressor
chr1_-_169888373 0.833 NM_000261
MYOC
myocilin, trabecular meshwork inducible glucocorticoid response
chr1_+_50342168 0.824 NM_001144776
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr9_+_35663852 0.822 NM_001216
CA9
carbonic anhydrase IX
chr1_-_224143389 0.821 NM_020997
LEFTY1
left-right determination factor 1
chr19_+_58239802 0.805 NM_001191055
HERV-V2
envelope glycoprotein ENVV2
chr19_-_12858956 0.800 NM_006563
KLF1
Kruppel-like factor 1 (erythroid)
chr11_-_66431910 0.783 NM_022172
PC
pyruvate carboxylase
chr9_+_6318348 0.742 NM_001001874
NM_001001875
NM_033516
TPD52L3


tumor protein D52-like 3


chr12_+_56114724 0.735 NM_005538
INHBC
inhibin, beta C
chr6_+_167456230 0.735 NM_031409
CCR6
chemokine (C-C motif) receptor 6
chr19_-_38052481 0.733 NM_001126335
NM_014270
SLC7A9

solute carrier family 7 (cationic amino acid transporter, y+ system), member 9

chr9_+_95886625 0.731 PTPDC1
protein tyrosine phosphatase domain containing 1
chr3_+_134976965 0.730 TF
transferrin
chr6_-_163068749 0.717 PARK2
parkinson protein 2, E3 ubiquitin protein ligase (parkin)
chr3_-_196792059 0.710 APOD
apolipoprotein D
chr1_+_6537924 0.703 NM_138697
NM_177540
TAS1R1

taste receptor, type 1, member 1

chr17_-_43390108 0.703 NM_024320
PRR15L
proline rich 15-like
chr14_-_93919305 0.675 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr9_+_114376709 0.672 KIAA1958
KIAA1958
chr6_-_30188845 0.659 NM_007028
TRIM31
tripartite motif containing 31
chr13_+_107720475 0.658 TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b
chr22_+_34979062 0.638 NM_001136540
NM_001136541
NM_003661
NM_145343
APOL1



apolipoprotein L, 1



chr6_-_11490487 0.631 NM_001142393
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr10_-_73518315 0.631 SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr7_+_129807467 0.630 NM_001868
CPA1
carboxypeptidase A1 (pancreatic)
chr16_+_4546491 0.625 NM_001145011
LOC342346
hypothetical protein LOC342346
chr7_+_94953148 0.622 NM_016116
NM_145872
ASB4

ankyrin repeat and SOCS box containing 4

chr5_-_88235624 0.619 NM_001131005
NM_001193347
MEF2C

myocyte enhancer factor 2C

chr13_+_107720561 0.613 TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b
chr7_+_138695236 0.611 LUC7L2
LUC7-like 2 (S. cerevisiae)
chr1_+_50344550 0.610 NM_001144775
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr5_-_131907071 0.599 NM_000879
IL5
interleukin 5 (colony-stimulating factor, eosinophil)
chr1_+_156842852 0.596 NM_001004478
OR10Z1
olfactory receptor, family 10, subfamily Z, member 1
chr10_+_89257569 0.587 NM_001178118
MINPP1
multiple inositol-polyphosphate phosphatase 1
chr11_-_16454493 0.586 NM_033326
SOX6
SRY (sex determining region Y)-box 6
chr1_+_205328834 0.584 NM_001017365
NM_001017366
C4BPB

complement component 4 binding protein, beta

chrX_-_55074125 0.578 NM_000032
NM_001037967
NM_001037968
ALAS2


aminolevulinate, delta-, synthase 2


chr9_+_95886558 0.571 NM_152422
PTPDC1
protein tyrosine phosphatase domain containing 1
chr13_+_107720206 0.570 TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b
chr2_-_55130963 0.570 RTN4
reticulon 4
chr7_-_92693716 0.569 NM_001039372
HEPACAM2
HEPACAM family member 2
chr7_+_138695209 0.567 LUC7L2
LUC7-like 2 (S. cerevisiae)
chr1_+_205329206 0.566 NM_000716
NM_001017364
NM_001017367
C4BPB


complement component 4 binding protein, beta


chr1_+_179164195 0.566


chr20_-_42457717 0.565


chr16_+_21623784 0.564 NM_170664
OTOA
otoancorin
chr11_+_65164167 0.564 NM_153253
SIPA1
signal-induced proliferation-associated 1
chr16_-_79811475 0.564 NM_001076780
NM_052892
PKD1L2

polycystic kidney disease 1-like 2

chr19_+_18069596 0.564 NM_015016
MAST3
microtubule associated serine/threonine kinase 3
chr17_+_53769562 0.560 LOC100506779
hypothetical LOC100506779
chr19_+_4442610 0.559 HDGFRP2
hepatoma-derived growth factor-related protein 2
chr19_+_61624 0.552 NM_001005240
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr3_-_10307408 0.551 NM_001134941
NM_016362
GHRL

ghrelin/obestatin prepropeptide

chr3_-_44527122 0.516 ZNF852
zinc finger protein 852
chr7_-_36992221 0.501 NM_130442
ELMO1
engulfment and cell motility 1
chr3_-_180467483 0.499 NM_001163677
NM_171828
KCNMB3

potassium large conductance calcium-activated channel, subfamily M beta member 3

chr6_-_163068706 0.498 PARK2
parkinson protein 2, E3 ubiquitin protein ligase (parkin)
chr3_-_44527083 0.497 ZNF852
zinc finger protein 852
chr10_-_69267774 0.496 NM_021800
NM_201262
DNAJC12

DnaJ (Hsp40) homolog, subfamily C, member 12

chr2_-_157892391 0.491 NM_001009959
ERMN
ermin, ERM-like protein
chr20_+_36643251 0.487 NM_001018082
ADIG
adipogenin
chr19_-_40996040 0.486 NM_021232
PRODH2
proline dehydrogenase (oxidase) 2
chr15_+_89248423 0.479 NM_006122
MAN2A2
mannosidase, alpha, class 2A, member 2
chr16_+_76613912 0.472 NM_005752
CLEC3A
C-type lectin domain family 3, member A
chr6_-_163068788 0.471 PARK2
parkinson protein 2, E3 ubiquitin protein ligase (parkin)
chr2_-_65013070 0.468 LOC400958
hypothetical LOC400958
chr12_-_6615348 0.468 NM_020400
LPAR5
lysophosphatidic acid receptor 5
chr17_+_40594046 0.465 NM_144608
HEXIM2
hexamthylene bis-acetamide inducible 2
chr7_-_99365178 0.461 NM_181538
GJC3
gap junction protein, gamma 3, 30.2kDa
chr21_-_26345294 0.460


chr6_-_33028790 0.456 NM_006120
HLA-DMA
major histocompatibility complex, class II, DM alpha
chr9_-_99746923 0.454 NM_018437
HEMGN
hemogen
chr11_-_116168316 0.452 NM_001166598
NM_052968
APOA5

apolipoprotein A-V

chr5_-_169657395 0.449 NM_005565
LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr12_-_53064723 0.444 NM_015481
ZNF385A
zinc finger protein 385A
chr16_+_56567839 0.444 NM_199046
NM_199456
TEPP

testis, prostate and placenta expressed

chr7_+_72883128 0.444 NM_001305
CLDN4
claudin 4
chr12_-_121753795 0.443 NM_177551
GPR109A
G protein-coupled receptor 109A
chr10_-_74384569 0.442 PLA2G12B
phospholipase A2, group XIIB
chr6_+_163068991 0.435 NM_001080379
PACRG
PARK2 co-regulated
chr2_-_55130925 0.433 RTN4
reticulon 4
chr11_-_614901 0.428 NM_001171968
NM_021924
NM_031264
CDHR5


cadherin-related family member 5


chr6_-_163068790 0.423 NM_004562
NM_013987
NM_013988
PARK2


parkinson protein 2, E3 ubiquitin protein ligase (parkin)


chr17_-_64568641 0.413 NM_080283
ABCA9
ATP-binding cassette, sub-family A (ABC1), member 9
chr7_+_138695241 0.411 LUC7L2
LUC7-like 2 (S. cerevisiae)
chr18_-_28606839 0.411 NM_020805
KLHL14
kelch-like 14 (Drosophila)
chr1_-_38185312 0.410 NM_005540
INPP5B
inositol polyphosphate-5-phosphatase, 75kDa
chr4_-_185921384 0.406 ACSL1
acyl-CoA synthetase long-chain family member 1
chr10_-_98311813 0.402 TM9SF3
transmembrane 9 superfamily member 3
chr15_+_56511466 0.401 NM_000236
LIPC
lipase, hepatic
chr14_-_93829309 0.395 SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr10_-_74384485 0.395 NM_032562
PLA2G12B
phospholipase A2, group XIIB
chr6_-_66473790 0.390 NM_001142800
NM_001142801
EYS

eyes shut homolog (Drosophila)

chr17_-_46479127 0.390 SPAG9
sperm associated antigen 9
chr12_-_8110268 0.390 C3AR1
complement component 3a receptor 1
chr2_-_183611470 0.388 NM_013436
NM_205842
NCKAP1

NCK-associated protein 1

chr13_+_107719977 0.385 NM_001145645
NM_006573
TNFSF13B

tumor necrosis factor (ligand) superfamily, member 13b

chr6_+_36318922 0.383 NM_173676
NM_001145716
PNPLA1

patatin-like phospholipase domain containing 1

chr12_+_61240542 0.369 MON2
MON2 homolog (S. cerevisiae)
chr6_-_41811323 0.367 TFEB
transcription factor EB
chr1_+_149221122 0.366 NM_003568
ANXA9
annexin A9
chr3_+_120982020 0.361 NM_003889
NM_033013
NR1I2

nuclear receptor subfamily 1, group I, member 2

chr6_-_56515640 0.359


chr5_-_178977441 0.350 HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr1_-_218286476 0.350 EPRS
glutamyl-prolyl-tRNA synthetase
chr22_-_34930705 0.349 NM_030643
NM_145660
APOL4

apolipoprotein L, 4

chr10_-_49792282 0.349 NM_001006939
LRRC18
leucine rich repeat containing 18
chr10_-_75127559 0.348 NM_001144000
AGAP5
ArfGAP with GTPase domain, ankyrin repeat and PH domain 5
chr19_-_11549484 0.345 ACP5
acid phosphatase 5, tartrate resistant
chr1_+_36545283 0.343 NM_024676
SH3D21
SH3 domain containing 21
chr4_+_39084936 0.342 KLB
klotho beta
chr2_+_187173176 0.329 NM_001144999
ITGAV
integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
chr4_+_48180033 0.325 NM_152679
SLC10A4
solute carrier family 10 (sodium/bile acid cotransporter family), member 4
chr17_+_35471971 0.323 NM_001190919
THRA
thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)
chr16_+_31105579 0.321


chr5_-_134810696 0.320 NM_130848
C5orf20
chromosome 5 open reading frame 20
chr22_+_24468168 0.319 MYO18B
myosin XVIIIB
chr10_+_80743769 0.318 ZMIZ1
zinc finger, MIZ-type containing 1
chr3_+_73193499 0.313 NM_018029
EBLN2
endogenous Borna-like N element-2
chrX_-_110400406 0.311 NM_014289
CAPN6
calpain 6
chr12_+_27740694 0.310 NM_001029874
REP15
RAB15 effector protein
chr6_-_31622372 0.309 ATP6V1G2
ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
chr4_+_39084867 0.309 NM_175737
KLB
klotho beta
chr10_+_85994788 0.302 NM_001012720
NM_001012722
NM_002921
RGR


retinal G protein coupled receptor


chr2_-_10860093 0.302 PDIA6
protein disulfide isomerase family A, member 6
chr20_-_44612619 0.301 NM_080721
C20orf123
chromosome 20 open reading frame 123
chr11_-_68505030 0.300 NM_198923
MRGPRD
MAS-related GPR, member D
chr7_+_138695144 0.299 NM_016019
LUC7L2
LUC7-like 2 (S. cerevisiae)
chr9_-_124280025 0.298 NM_001004451
OR1J1
olfactory receptor, family 1, subfamily J, member 1
chr7_+_94130752 0.295 PEG10
paternally expressed 10
chr16_+_51690564 0.294 CHD9
chromodomain helicase DNA binding protein 9
chr12_-_8110196 0.292 NM_004054
C3AR1
complement component 3a receptor 1
chr11_+_5558682 0.287 NM_001005162
OR52B6
olfactory receptor, family 52, subfamily B, member 6
chr12_-_52016270 0.287 NM_001173467
SP7
Sp7 transcription factor
chr2_+_68445821 0.287 NM_002664
PLEK
pleckstrin
chr12_-_120725210 0.286 LOC338799
hypothetical LOC338799
chr17_-_16816113 0.285 NM_012452
TNFRSF13B
tumor necrosis factor receptor superfamily, member 13B
chr12_-_69434650 0.284 PTPRR
protein tyrosine phosphatase, receptor type, R

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.46 4.02e-07 GO:0007606 sensory perception of chemical stimulus
3.53 1.60e-06 GO:0007608 sensory perception of smell
2.46 8.80e-05 GO:0007600 sensory perception
2.01 5.17e-04 GO:0050877 neurological system process
1.73 2.57e-02 GO:0003008 system process

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.70 1.15e-07 GO:0004984 olfactory receptor activity
2.43 1.97e-05 GO:0004930 G-protein coupled receptor activity
1.91 3.91e-05 GO:0004872 receptor activity
2.02 1.77e-04 GO:0004888 transmembrane receptor activity
1.70 8.96e-04 GO:0004871 signal transducer activity
1.70 8.96e-04 GO:0060089 molecular transducer activity